abstract：:The Egyptian flora is rich with a large number of Triticum plants, which are very difficult to discriminate between in the early developmental stages. This study assesses the significance of using two DNA Barcoding loci (matK and rbcL) in distinguishing between 18 different Triticum accessions in Egypt. We isolated an...

journal_title：Computational biology and chemistry

authors： Awad M,Fahmy RM,Mosa KA,Helmy M,El-Feky FA

更新日期：2017-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small (19-25 base long), non-coding RNAs that regulate post-transcriptional gene expression by cleaving targeted mRNAs in several eukaryotes. The miRNAs play vital roles in multiple biological and metabolic processes, including developmental timing, signal transduction, cell maintenance and diff...

journal_title：Computational biology and chemistry

authors： Manku HK,Dhanoa JK,Kaur S,Arora JS,Mukhopadhyay CS

更新日期：2017-10-01 00:00:00

abstract：:Drug-target interaction (DTI) prediction is a challenging step in further drug repositioning, drug discovery and drug design. The advent of high-throughput technologies brings convenience to the development of DTI prediction methods. With the generation of a high number of data sets, many mathematical models and compu...

journal_title：Computational biology and chemistry

authors： Zhang X,Li L,Ng MK,Zhang S

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Associating protein complexes to human inherited diseases is critical for better understanding of biological processes and functional mechanisms of the disease. Many protein complexes have been identified and functionally annotated by computational and purification methods so far, however, the particular rol...

journal_title：Computational biology and chemistry

authors： Liu Z,Luo J

更新日期：2017-08-01 00:00:00

abstract：:Recent advances in high-throughput genome sequencing technologies have enabled the systematic study of various genomes by making whole genome sequencing affordable. Modern sequencers generate a huge number of small sequence fragments called reads, where the read length and the per-base sequencing cost depend on the te...

journal_title：Computational biology and chemistry

authors： Chen CC,Ghaffari N,Qian X,Yoon BJ

更新日期：2017-08-01 00:00:00

abstract：:Polyphenol oxidases (PPOs)/tyrosinases are metal-dependent enzymes and known as important targets for melanogenesis. Although considerable attempts have been conducted to control the melanin-associated diseases by using various inhibitors. However, the exploration of the best anti-melanin inhibitor without side effect...

journal_title：Computational biology and chemistry

authors： Hassan M,Abbas Q,Ashraf Z,Moustafa AA,Seo SY

更新日期：2017-06-01 00:00:00

abstract：:The single-stranded transfer DNA from the Ti plasmid of the soil bacteria Agrobacterium nonspecifically integrates into the plant chromosome and is inherited at subsequent cell divisions. How it is transferred across host membranes is unknown, but it is believed that VirE2 proteins form a membrane-spanning pore or cha...

journal_title：Computational biology and chemistry

authors： Volokhina I,Gusev Y,Mazilov S,Moiseeva Y,Chumakov M

更新日期：2017-06-01 00:00:00

abstract：:The P-type ATPases (P-ATPases) are present in all living cells where they mediate ion transport across membranes on the expense of ATP hydrolysis. Different ions which are transported by these pumps are protons like calcium, sodium, potassium, and heavy metals such as manganese, iron, copper, and zinc. Maintenance of ...

journal_title：Computational biology and chemistry

authors： Seddigh S

更新日期：2017-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease of central nervous system among elderly people. Human acetylcholinesterase (hAChE), an important enzyme in neuronal signaling, is responsible for the degradation of acetylcholine which in turn prevents the post synaptic signal transmissions. hAChE has...

journal_title：Computational biology and chemistry

authors： Singh SP,Gupta D

更新日期：2017-06-01 00:00:00

abstract：:Nodulation is one of the very important processes of legume plants as it is the initiating event of fixing nitrogen. Although ethylene has essential role in normal plant metabolism but it has also negative impact on plants particularly in nodule formation in legume plants. It is also produced due to a variety of bioti...

journal_title：Computational biology and chemistry

authors： Pramanik K,Soren T,Mitra S,Maiti TK

更新日期：2017-06-01 00:00:00

abstract：:Cyclin-Dependent Kinases (CDKs) are known to play crucial roles in controlling cell cycle progression of eukaryotic cell and inhibition of their activity has long been considered as potential strategy in anti-cancer drug research. In the present work, a series of porphyrin-anthraquinone hybrids bearing meso-substituen...

journal_title：Computational biology and chemistry

authors： Arba M,Ihsan S,Ramadhan OA,Tjahjono DH

更新日期：2017-04-01 00:00:00

abstract：:Cytosine methylation is one of the most important RNA epigenetic modifications. With the development of experimental technology, scientists attach more importance to RNA cytosine methylation and find bisulfite sequencing is an effective experimental method for RNA cytosine methylation study. However, there are only a ...

journal_title：Computational biology and chemistry

authors： Liang F,Hao L,Wang J,Shi S,Xiao J,Li R

更新日期：2016-12-01 00:00:00

abstract：:In many sequence data mining applications, the goal is to find frequent substrings. Some of these applications like extracting motifs in protein and DNA sequences are looking for frequently occurring approximate contiguous substrings called simple motifs. By approximate we mean that some mismatches are allowed during ...

journal_title：Computational biology and chemistry

authors： Pari A,Baraani A,Parseh S

更新日期：2016-10-01 00:00:00

abstract：:Adenosine deaminase (ADA) is an enzyme involved in purine metabolism. ADA converts adenosine to inosine and liberates ammonia. Because of their critical role in the differentiation and maturation of cells, the regulation of ADA activity is considered as a potential therapeutic approach to prevent malignant and inflamm...

journal_title：Computational biology and chemistry

authors： Arun KG,Sharanya CS,Sandeep PM,Sadasivan C

更新日期：2016-10-01 00:00:00

abstract：:The structural and dynamical properties of five FMN binding protein (FBP) dimers, WT (wild type), E13K (Glu13 replaced by Lys), E13R (Glu13 replaced by Arg), E13T (Glu13 replaced by Thr) and E13Q (Glu13 replaced by Gln), were investigated using a method of molecular dynamics simulation (MDS). In crystal structures, su...

journal_title：Computational biology and chemistry

authors： Nunthaboot N,Lugsanangarm K,Pianwanit S,Kokpol S,Tanaka F,Nakanishi T,Kitamura M

更新日期：2016-10-01 00:00:00

abstract：:The eukaryotic chaperonin, CCT (Chaperonin Containing TCP1 or TriC-TCP-1 Ring Complex) has been subjected to physical and genetic analyses in S. cerevisiae which can be extrapolated to human CCT (hCCT), owing to its structural and functional similarities with yeast CCT (yCCT). Studies on hCCT and its interactome acqui...

journal_title：Computational biology and chemistry

authors： Narayanan A,Pullepu D,Kabir MA

更新日期：2016-10-01 00:00:00

abstract：:The channel blocker picrotoxinin has been studied with GABAA-ρ1 and GABAA-ρ2 homology models based on the GluCl crystal structure. Picrotoxinin is tenfold more potent for GABAA-ρ2 than for GABAA-ρ1 homomeric channels. This intra-subunit selectivity arises from the unconserved residues at the 2' sites, which are the es...

journal_title：Computational biology and chemistry

authors： Naffaa MM,Samad A

更新日期：2016-10-01 00:00:00

abstract：:Triticum aestivum L. known as common wheat is one of the most important cereal crops feeding a large and growing population. Various environmental stress factors including drought, high salinity and heat etc. adversely affect wheat production in a significant manner. Dehydration-responsive element-binding (DREB1A) fac...

journal_title：Computational biology and chemistry

authors： Kumar A,Kumar S,Kumar U,Suravajhala P,Gajula MN

更新日期：2016-10-01 00:00:00

abstract：:In this study, the dipeptidyl peptidase-IV (DPP-IV) inhibition activities of a series of novel aminomethyl-piperidones were investigated by molecular docking studies and modeled by quantitative structure-activity relationship (QSAR) methodology. Molecular docking studies were used to find the best conformations of the...

journal_title：Computational biology and chemistry

authors： Amini Z,Fatemi MH,Gharaghani S

更新日期：2016-10-01 00:00:00

abstract：:Shortest common supersequence (SCS) is a classical NP-hard problem, where a string to be constructed that is the supersequence of a given string set. The SCS problem has an enormous application of data compression, query optimization in the database and different bioinformatics activities. Due to NP-hardness, the exac...

journal_title：Computational biology and chemistry

authors： Khaled Saifullah CM,Rafiqul Islam M

更新日期：2016-10-01 00:00:00

abstract：:Human Leukocyte Antigens (HLA) are highly polymorphic proteins that play a key role in the immune system. HLA molecule is present on the cell membrane of antigen-presenting cells of the immune system and presents short peptides, originating from the proteins of invading pathogens or self-proteins, to the T-cell Recept...

journal_title：Computational biology and chemistry

authors： Ozbek P

更新日期：2016-06-01 00:00:00

abstract：:The metabolic rearrangements occurring in cancer cells can be effectively investigated with a Systems Biology approach supported by metabolic network modeling. We here present tissue-specific constraint-based core models for three different types of tumors (liver, breast and lung) that serve this purpose. The core mod...

journal_title：Computational biology and chemistry

authors： Di Filippo M,Colombo R,Damiani C,Pescini D,Gaglio D,Vanoni M,Alberghina L,Mauri G

更新日期：2016-06-01 00:00:00

abstract：:The chaetognaths constitute a small and enigmatic phylum of little marine invertebrates. Both nuclear and mitochondrial genomes have numerous originalities, some phylum-specific. Until recently, their mitogenomes seemed containing only one tRNA gene (trnMet), but a recent study found in two chaetognath mitogenomes two...

journal_title：Computational biology and chemistry

authors： Barthélémy RM,Seligmann H

更新日期：2016-06-01 00:00:00

abstract：:As a mode of reproduction in plants, apomixis leads to the generation of clones via seeds. Apomictic plants form viable diploid female gametes without meiosis (apomeiosis) and produce embryos without fertilization (parthenogenesis). Apomeiosis, as a major component of apomixis, has recently been reported in some Arabi...

journal_title：Computational biology and chemistry

authors： Sezer F,Yüzbaşioğlu G,Özbilen A,Taşkin KM

更新日期：2016-06-01 00:00:00

abstract：:Protein structure prediction is considered as one of the most challenging and computationally intractable combinatorial problem. Thus, the efficient modeling of convoluted search space, the clever use of energy functions, and more importantly, the use of effective sampling algorithms become crucial to address this pro...

journal_title：Computational biology and chemistry

authors： Rashid MA,Iqbal S,Khatib F,Hoque MT,Sattar A

更新日期：2016-04-01 00:00:00

abstract：:The presence of repetitive or non-unique DNA persisting over sizable regions of a eukaryotic genome can hinder the genome's successful de novo assembly from short reads: ambiguities in assigning genome locations to the non-unique subsequences can result in premature termination of contigs and thus overfragmented assem...

journal_title：Computational biology and chemistry

authors： Misas E,Muñoz JF,Gallo JE,McEwen JG,Clay OK

更新日期：2016-04-01 00:00:00

abstract：:Human intestinal absorption (HIA) of the drugs administered through the oral route constitutes an important criterion for the candidate molecules. The computational approach for predicting the HIA of molecules may potentiate the screening of new drugs. In this study, ensemble learning (EL) based qualitative and quanti...

journal_title：Computational biology and chemistry

authors： Basant N,Gupta S,Singh KP

更新日期：2016-04-01 00:00:00

abstract：:The DNA binding protein, TDP43 is a major protein involved in amyotrophic lateral sclerosis and other neurological disorders such as frontotemporal dementia, Alzheimer disease, etc. In the present study, we have designed possible siRNAs for the glycine rich region of tardbp mutants causing ALS disorder based on a syst...

journal_title：Computational biology and chemistry

authors： Bhandare VV,Ramaswamy A

更新日期：2016-04-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Computational biology and chemistry

authors： Liu B,Fang L

更新日期：2016-02-17 00:00:00

abstract：:Non-specific lipid transfer proteins (nsLTPs) are common allergens and they are particularly widespread within the plant kingdom. They have a highly conserved three-dimensional structure that generate a strong cross-reactivity among the members of this family. In the last years several web tools for the prediction of ...

journal_title：Computational biology and chemistry

authors： Garino C,Coïsson JD,Arlorio M

更新日期：2016-02-01 00:00:00

abstract：:We present the mechanism of interaction of Wnt network module, which is responsible for periodic somitogenesis, with p53 regulatory network, which is one of the main regulators of various cellular functions, and switching of various oscillating states by investigating p53-Wnt model. The variation in Nutlin concentrati...

journal_title：Computational biology and chemistry

authors： Zubbair Malik M,Ali S,Alam MJ,Ishrat R,Brojen Singh RK

更新日期：2015-12-01 00:00:00

abstract：:Structural class characterizes the overall folding type of a protein or its domain. Many methods have been proposed to improve the prediction accuracy of protein structural class in recent years, but it is still a challenge for the low-similarity sequences. In this study, we introduce a feature extraction technique ba...

journal_title：Computational biology and chemistry

authors： Li X,Liu T,Tao P,Wang C,Chen L

更新日期：2015-12-01 00:00:00

abstract：:Multiple ligand simultaneous docking, a computational approach is used to study the concurrent interactions between substrate and the macromolecule binding together in the presence of an inhibitor. The present investigation deals with the study of the effect of different inhibitors on binding of substrate to the prote...

journal_title：Computational biology and chemistry

authors： Raghavendra S,Aditya Rao SJ,Kumar V,Ramesh CK

更新日期：2015-12-01 00:00:00

abstract：:With advances in genomics, transcriptomics, metabolomics and proteomics, and more expansive electronic clinical record monitoring, as well as advances in computation, we have entered the Big Data era in biomedical research. Data gathering is growing rapidly while only a small fraction of this data is converted to usef...

journal_title：Computational biology and chemistry

authors： Rouillard AD,Wang Z,Ma'ayan A

更新日期：2015-12-01 00:00:00

abstract：:Detection of protein complexes is very important to understand the principles of cellular organization and function. Recently, large protein-protein interactions (PPIs) networks have become available using high-throughput experimental techniques. These networks make it possible to develop computational methods for pro...

journal_title：Computational biology and chemistry

authors： Lakizadeh A,Jalili S,Marashi SA

更新日期：2015-10-01 00:00:00

abstract：:Bacterial MocR transcriptional regulators possess an N-terminal DNA-binding domain containing a conserved helix-turn-helix module and an effector-binding and/or oligomerization domain at the C-terminus, homologous to fold type-I pyridoxal 5'-phosphate (PLP) enzymes. Since a comprehensive structural analysis of the Moc...

journal_title：Computational biology and chemistry

authors： Milano T,Contestabile R,Lo Presti A,Ciccozzi M,Pascarella S

更新日期：2015-10-01 00:00:00

abstract：:The growth and spread of drug resistance in bacteria have been well established in both mankind and beasts and thus is a serious public health concern. Due to the increasing problem of drug resistance, control of infectious diseases like diarrhea, pneumonia etc. is becoming more difficult. Hence, it is crucial to unde...

journal_title：Computational biology and chemistry

authors： Tamanna,Ramana J

更新日期：2015-10-01 00:00:00

abstract：:Momordica charantia (bitter gourd, bitter melon) is a monoecious Cucurbitaceae with anti-oxidant, anti-microbial, anti-viral and anti-diabetic potential. Molecular studies on this economically valuable plant are very essential to understand its phylogeny and evolution. MicroRNAs (miRNAs) are conserved, small, non-codi...

journal_title：Computational biology and chemistry

authors： Thirugnanasambantham K,Saravanan S,Karikalan K,Bharanidharan R,Lalitha P,Ilango S,HairulIslam VI

更新日期：2015-10-01 00:00:00

abstract：:Interleukin-1β is a drug target in rheumatoid arthritis and several auto-immune disorders. In this study, a set of 48 compounds with the determined IC50 values were used for QSAR analysis by MOE. The QSAR model was developed by using training set of 41 compounds, based on 12 unique descriptors. Model was validated by ...

journal_title：Computational biology and chemistry

authors： Halim SA,Jawad M,Ilyas M,Mir Z,Mirza AA,Husnain T

更新日期：2015-10-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) protease is an attractive target when developing inhibitors to treat HTLV-1 associated diseases. To study the catalytic mechanism and design novel HTLV-1 protease inhibitors, the protonation states of the two catalytic aspartic acid residues must be determined. Free energy s...

journal_title：Computational biology and chemistry

authors： Ma S,Vogt KA,Petrillo N,Ruhoff AJ

更新日期：2015-06-01 00:00:00